(English version at the end of the document)

En tre-årig stilling som ph.d.-studerende ved Klinisk Biokemisk Afdeling, Sjællands Universitetshospital – Roskilde, Region Sjælland, opslås til besættelse 01.01.18 eller snarest derefter.

Du vil blive indskrevet som ph.d.-studerende på Det Sundhedsvidenskabelige Fakultet, Københavns Universitet. Ph.d.-projektet omhandler cancerimmunologi. Immunceller strømmer normalt til en kræfttumor, og de besidder anti-tumoraktivitet. Denne aktivitet nedreguleres imidlertid ofte af signaler fra tumoren, hvilket kan føre til en væsentlig dårligere prognose for patienten. Vi forsøger at klarlægge specifikke mekanismer, der fører til en undvigelse af et immunrespons mod canceren (tumor escape). I forskningsprojekterne, der kommer til at indgå i ph.d.-studiet, undersøges betydningen af immunmarkørprofiler for immunreguleringen og immunsystemets respons mod cancerceller lokalt i og omkring tumoren, herunder individuelle forskelle på dette respons af betydning for personlig medicin. Der vil være fokus på brystcancer, lungecancer og modermærkekræft (malignt melanom). Resultater fra disse undersøgelser kan få betydning for forbedringer af cancerimmunterapi-behandlinger.

Du vil have fast base på Klinisk Biokemisk Afdeling, Sjællands Universitetshospital (Roskilde), hvor hovedparten af det eksperimentelle arbejde også foregår. Ph.d.-delprojekterne vil imidlertid blive gennemført i et samarbejde med flere andre afdelinger og specialer på hospitalet, samt nationale og internationale samarbejdspartnere.

Forskningsgruppen består af en professor, en postdoc, ph.d.-studerende, medicinstuderende/skolarstipendiater, specialestuderende, samt forskningsbioanalytikere. Derudover er der i afdelingen flere fastansatte biokemikere/molekylærbiologer og læger, der også er forskningsaktive og som varetager specialfunktioner af stor relevans for gennemførelsen af afdelingens forskning (molekylærbiologiske analyser, ‘Next Generation Sequencing’, bioinformatik, flowcytometri etc), og som indgår i forskningssamarbejdet.

Vores forskning omhandler tre fokusområder, der har overlappende elementer, hvilket giver en god synergieffekt i gennemførelsen af de enkelte forskningsprojekter:

1) Regulering af immunsystemet: Omhandler både klinisk relaterede og mere basalvidenskabelige undersøgelser af regulerende mekanismer i immunforsvaret.

2) Reproduktionsimmunologi: Undersøgelser af de mekanismer, der modulerer kvindens immunrespons ved kontakten med det delvist vævsfremmede foster, og immunmekanismer som har betydning for implantation, fertilitet, udvikling af præeklampsi (svangerskabsforgiftning), gentagne spontane aborter og succes ved assisteret reproduktion.

3) Cancerimmunologi: Som beskrevet ovenfor.

Vi er meget interesseret i en ny ph.d.-studerende, der er særligt interesseret i biomedicinsk forskning. Derfor er personligt engagement, virkelyst og initiativ vigtige forudsætninger, og de vigtigste kvalifikationer er følgende: God til at organisere og holde gang i flere aktiviteter samtidigt. Du skal endvidere være målrettet, fokuseret og kunne afslutte projekterne. Fremfor alt forventer vi, at du brænder for forskning og besidder en fundamental nysgerrighed for at studere og klarlægge biomedicinske sammenhænge og mekanismer, der i sidste ende kan få en betydning for behandling af sygdomme.

Klinisk biokemi er et spændende tværfagligt lægevidenskabeligt speciale, hvor bred biomedicinsk forskning er en hjørnesten. Forskningen rummer i særdeleshed klinisk relateret forskning i samarbejde med hospitalernes kliniske og parakliniske afdelinger, men også basalvidenskabelig forskning blandt andet i samarbejde med universitetsinstitutter. Specialet er således centralt placeret i et dynamisk krydsfelt, hvor lægevidenskab, biokemi, molekylærbiologi, genetik og bioinformatik er vigtige elementer. Det aktuelle ph.d.-projekt indeholder alle disse aspekter og muligheder.

Der forventes følgende kvalifikationer

Læge (cand.med.) eller cand.scient. Dokumenteret forskningsaktivitet vil være en klar fordel.

Løn- og ansættelsesforhold

Ansættelse i henhold til gældende overenskomst.

Yderligere spørgsmål

Kontakt rettes til professor, overlæge, ph.d., dr.med. Thomas Hviid, 47 32 56 22 eller 23 32 77 45 (eventuelt 47 32 56 00), tvh@regionsjaelland.dk.

Send din ansøgning med bilag via knappen Søg jobbet

Ansøgningen bør indeholde følgende bilag

1. Et følgebrev der beskriver, hvorfor du er interesseret i at gennemføre et ph.d.-studie og i særdeleshed, hvorfor du er interesseret i at være aktiv forsker, og hvad du kan bidrage med i forskningsgruppen og i afdelingen ved en ansættelse.
2. CV (med publikationsliste).
3. Diverse eksamenspapirer og titeldiplomer (også gerne studentereksamensbevis eller tilsvarende)

English version

PhD Project at the Department of Clinical Biochemistry, Zealand University Hospital

Three year position as PhD student at the Department of Clinical Biochemistry – Roskilde, Zealand University Hospital, Region Zealand, from 01 January 2018 or soon thereafter.

As a PhD student you will be enrolled at the Faculty of Health and Medical Sciences at the University of Copenhagen. The PhD project focuses on cancer immunology. Immune effector cells are recruited to tumor sites, and they will have antitumor activity. However, often this activity is down-regulated by tumor-derived signals, which may lead to a significantly worse prognosis for the patient. We try to elucidate specific mechanisms that lead to tumor escape from the host immune system. In the research projects included in the PhD, the importance of immune marker profiles for the regulation of the immune system in the tumor microenvironment is investigated, including individual differences in the response, which is of importance for personalized medicine. The focus will be on breast cancer, lung cancer and malignant melanoma. Results obtained from the studies may be important for improving cancer immune therapy.

You will be located in the Department of Clinical Biochemistry, Zealand University Hospital (Roskilde), where most of the experimental work is performed. However, the project involves several collaborations with researchers from other departments in the hospital, as well with national and international collaborators. We collaborate with clinical departments, other hospital laboratories and basic research institutes at the universities.

The research group consists of a Professor, a Postdoc, PhD Students, Medical Scholars and Students, Master’s Degree Students, and Research Technicians. Furthermore, several Biochemists, Molecular Biologists, and Medical Doctors are employed in the department and function as part of the research collaboration. All members of the research group are active in research and manage special assignments of importance for the execution of the research in the department (e.g. molecular biology techniques, Next Generation Sequencing, bioinformatics, flow cytometry etc).

Our research focuses on three interacting areas, thereby resulting in synergy in the accomplishment of our research projects:

1) Regulation of the immune system: Basic and clinical investigations of the mechanisms that regulate the immune system. This involves biochemical immunology, molecular biology, immunogenetics and cellular immunology.

2) Reproductive immunology: Investigations of the mechanisms that modulate the pregnant woman’s immune response in the contact with the semi-allogenic embryo at the feto-maternal interface, and immune mechanisms of importance for implantation, fertility, development of preeclampsia, recurrent spontaneous abortions and assisted reproductive technology.

3) Cancer immunology: As described above.

We are in search of a new PhD student, who is very interested in biomedical research. Therefore, personal commitment, enterprise, and initiative are important conditions, and the most important qualifications are the following: You should be good at organizing different assignments in parallel. Also, you should be goal-oriented, focused and able to complete projects. Most of all, we expect that you are passionate about research and that you possess a fundamental curiosity dedicated towards the discovery and elucidation of biomedical mechanisms and pathophysiology, which ultimately may be of great importance for medical treatment.

Clinical Biochemistry is an interesting interdisciplinary medical speciality, where biomedical research is a cornerstone. The research involves clinical related research in collaboration with clinical and paraclinical hospital departments, as well as basic research that involves collaboration with university departments. Thereby, Clinical Biochemistry is a key player in a dynamic intersection, where medicine, biochemistry, molecular biology, genetics and bioinformatics are important elements. The current PhD project involves all these aspects and opportunities.

Qualifications

Candidates for the position should hold a Medical Degree or a Master of Science Degree. Documented scientific experience will be an advantage.

Salary and appointment terms

The salary and appointment terms are consistent with the current rules in the field.

Further information

For further information please contact Professor, Chief Physician Thomas Hviid, MD, PhD, DMSc at +45-4732-5622 or +45-2332-7745 (or 45-4732-5600) or e-mail: tvh@regionsjaelland.dk.

Application procedure

We must have your application no later than by the 12th of November 2017. The application should contain the following documents

1. A letter of motivation describing your interest in this position and what you can offer to the department.
2. A CV (including list of publications)
3. Grade transcripts and BSc/MSc diploma